MICROFLUIDICS & LAB-ON-A-CHIP RESEARCH GROUP (MLRG)

ACTIVITIES:

The miniaturization trend of electronic components since 1970’s and the development of advanced fabrication techniques for micro and nanoscale devices since 1980’s led to the usage of devices having the dimensions of micrometers and nanometers in many fields. As a consequence a field of microfluidics which deals with fluid flow phenomena at microscale became an interesting, rich research field. Fundamental understanding of the fluid, thermal and mass transport at microscale is very critical for the design and process control of the microfluidic systems.

Lab-on-a-chip (LOC) devices are the microfluidic platforms that can integrate complex chemical management and analysis systems onto one chip just millimeters or centimeters in size and can be interfaced with electronics and optical detection systems. The ultimate goal of the LOC technology is to develop portable devices that can accomplish the same analytical tasks fast and accurately as its room-sized or benchtop-sized counterparts, however, at much lower manufacturing and operational cost, and more importantly which can accomplish in-situ testing and detection. This kind of devices are being demanded by life sciences, space explorations, defense industry, atmospheric sciences, pharmaceutical research etc.

Bilkent University Microfluidics & Lab-on-a-chip Research Group (BU-MLRG)’s interest lies in the fundamental and experimental investigations on transport phenomena in microchannel networks and development of the LOC technology for biomedical, biological and chemical applications.

PROJECTS

RELATED PUBLICATIONS

  • Özer, M.B., Çetin, B. (2021). "An extended view for acoustofluidic particle manipulation: Scenarios for actuation modes and device resonance phenomenon for bulk-acoustic-wave devices,", J. Acoust. Soc. Am., v.149(4) p.2802–2812, Full Text
  • Aşık, M.D., Kaplan, M., Çetin, B., Sağlam, N. (2021). "Synthesis of iron oxide core chitosan nanoparticles in a 3D printed microfluidic channel", J. Nanopart. Res., v.23(3) p.62, Full Text
  • Sabuncu, A.C., Çetin, B., Usta, O.B., Aubry, N. (2021). "β-dispersion of blood during sedimentation.", Scientific Reports, v.11(1) p.2642, Full Text
  • Atay, A., Topuz, A., Sarıarslan, B., Yıldırım, Y., Charmet, J., Couling, K., Çetin, B. (2021). "Flow rate-controlled pipetting for microfluidics: second-generation flexible hydraulic reservoir (FHRv2)", Microfluid. Nanofluid., v.25(3) p.1-10, Full Text
  • Çetin, B., Kuşcu, Y.F., Çetin, B., Tümüklü, Ö., Cole, K.D. (2021). "Semi-analytical source (SAS) method for 3-D transient heat conduction problems with moving heat source.", Int. J. Heat Mass Trans., v.165 p.120692, Full Text
  • Akkuş, Y., Çetin, B., Dursunkaya, Z. (2020). "A theoretical framework for comprehensive modeling of steadily fed evaporating droplets and the validity of common assumptions", Int. J. Thermal Sciences, v.158 p.106529, Full Text
  • Şahin, M.A., Çetin, B., Özer, M.B. (2020). "Investigation of effect of design and operating parameters on acoustophoretic particle separation via 3D device-level simulations", Microfluid. Nanofluid., v.24(8) p.1-18, Full Text
  • Rasooli, R., Çetin, B. (2019). "An extended Langhaar's solution for two-dimensional entry microchannel flows with high-order slip", Mathematics Applied to Engineering, Modelling, and Social Issues (Editors: Frank Smith, Hemen Dutta and John N. Mordeson), Springer p.189-212, Full Text
  • Çelebi, A.T., Çetin, B., Beşkök, A. (2019). "Molecular and Continuum Perspectives on Intermediate and Flow Reversal Regimes in Electroosmotic Transport", J. Physical Chemistry C, v.123(22) p.14024-14035, Full Text
  • Düven, G., Çetin, B., Kurtuldu, H., Gündüz, G.T., Tavman, Ş., Kışla, D. (2019). "A portable microfluidic platform for rapid determination of microbial load and somatic cell count", Biomed. Microdev., v.21(3) p.49, Full Text
  • Kibar, G., Çalışkan, U., Erdem, Y., Çetin, B. (2019). "One-pot synthesis of polyhedral oligomeric silsesquiox- ane (POSS) microparticles in a microfluidic chip", Full Text
  • Atay, A., Sarıarslan, B., Kuşcu, Y.F., Akkuş, Y., Saygan, S., Gürer, T., Çetin, B., Dursunkaya, Z. (2019). "Experimental dryout characterization of commercial sintered and grooved heat pipes", J. Thermal Science & Technology, v.39(2) p.101-110
  • Akkuş, Y., Çetin, B., Dursunkaya, Z. (2019). "An iterative solution approach to coupled heat and mass transfer in a steadily fed evaporating water droplet", J. Heat Transfer, v.141(2) p.031501, Full Text
  • Alijani, H., Çetin, B., Akkus, Y., Dursunkaya, Z. (2019). "Experimental thermal performance characterization of flat grooved heat pipes", Heat Transfer Engineering, v.40(9-10) p.784–793, Full Text
  • Rasooli, R., Çetin, B. (2018). "Assessment of Lagrangian modeling of particle motion in a spiral microchannel for inertial microfluidics", Micromachines, v.9(9) p.433, Full Text
  • Hatipoğlu, U., Çetin, B., Yıldırım, E. (2018). "A novel zero-dead-volume sample loading interface for microfluidic devices: Flexible Hydraulic Reservoir (FHR)", J. Micromech. Microeng., v.28(9) p.097001, Full Text
  • Oskay, Y., Çetin, B., Şerifoğlu, N., Arslan Ergül, A., Adams, M. (2018). "A novel, low-cost injection and anesthesia system for zebrafish researchers", Zebrafish, v.15(2) p.85-95, Full Text
  • Cole, K., Çetin, B., Demirel, Y. (2018). "Semi-analytical source method for reaction-diffusion problem", J. Heat Transfer, v.140(6) p.061301, Full Text, DOI: http://dx.doi.org/10.1115/1.4038987
  • Düven, G., Çetin, B., Kışla, D. (2018). "Çip-üstü-laboratuvar teknolojisinin gıda mikrobiyolojisindeki uygulamaları (Lab-on-a-chip technology in food microbiology)", Akademik Gıda (Academic Food), v.16(1) p.78-87, Full Text, DOI: http://dx.doi.org/10.24323/akademik-gida.417895
  • Alijani, H., Çetin, B., Akkus, Y., Dursunkaya, Z. (2018). "Effect of design and operating parameters on the thermal Performance of flat grooved heat pipes", Applied Thermal Engineering, v.132 p.174-187, Full Text
  • Yıldıran, İ.N., Temizer, İ., Çetin, B. (2017). "Homogenization in Hydrodynamic Lubrication: Microscopic Regimes and Re-Entrant Textures", Journal of Tribology, v.140 p.011701 (1-19), Full Text, DOI: http://tribology.asmedigitalcollection.asme.org/article.aspx?articleid=2628741
  • Çetin, B., Güler, K.G., Aksel, M.H. (2017). "Computational modeling of vehicle radiators using porous medium approach", Heat Exchangers -- Design, Experiment and Simulation (Edited by Prof. S. M. Sohel Murshed, Prof. M. L. S. Matos Lopes) InTech p.243–262, Full Text
  • Akkuş, Y., Tarman, H.İ., Çetin, B., Dursunkaya, Z. (2017). "Two-dimensional computational modeling of thin film evaporation", Int. J. Thermal Sciences, v.121 p.237–248, Full Text
  • Cole, K.D., Çetin, B. (2017). "Modeling of Joule heating and convective cooling in a thick-walled micro-tube", Int. J. Thermal Sciences, v.119 p.24-36, Full Text
  • Çetin, B., Öner, S.D., Baranoğlu, B. (2017). "Modeling of dielectrophoretic particle motion: Point particle vs finite-sized particle", Electrophoresis, v.38 p.1407-1418, Full Text, DOI: http://dx.doi.org/10.1002/elps.201600461
  • Kerse, C., Kalaycıoğlu, H., Elahi, P., Yavaş, S., Kesim, D., Akçaalan, Ö., Öktem, B., Çetin, B., Aşık, M., Hoogland, H., Holzwarth, R., İlday, F.Ö. (2016). "Ablation-cooled material removal with ultrafast bursts of pulses", Nature, v.537 p.84-88, Full Text, DOI: http://dx.doi.org/doi:10.1038/nature18619
  • Çetin, B., Özer, M.B., Çağatay, E., Büyükkoçak, S. (2016). "An integrated acoustic and dielectrophoretic particle manipulation in a microfluidic device for particle wash and separation fabricated by mechanical machining", Biomicrofluidics, v.10 p.014112, Full Text, DOI: http://dx.doi.org/http://dx.doi.org/10.1063/1.4940431
  • Yavuz, C., Oliaei, S.N., Çetin, B., Yeşil-Çeliktaş, Ö. (2016). "Sterilization of PMMA microfluidic chips by various techniques and investigation of material characteristics", J. Supercrticial Fluids, v.107 p.114–121, Full Text, DOI: http://dx.doi.org/10.1016/j.supflu.2015.08.019
  • Çetin, B., Yıldırım, E., Akay, Ş. (2016). "Mikroakışkan Sistemlerin Üretimi", Mikroakışkan Teknolojilerin Temelleri ve Uygulamaları (Edited by Assoc. Prof. Ö. Yeşil-Çeliktaş) p.27–51
  • Yavuz, C., Çetin, B., Yeşil-Çeliktaş, Ö. (2016). "Mikroakışkan Sistemlerin Sterilizasyonu", Mikroakışkan Teknolojilerin Temelleri ve Uygulamaları (Edited by Assoc. Prof. Ö. Yeşil-Çeliktaş) p.115–137
  • Yeşil-Çeliktaş, Ö., Çetin, B., Yıldırım, E. (2016). "Mikroakışkan Sistemlere Yönelik Gelecek Tahminleri", Mikroakışkan Teknolojilerin Temelleri ve Uygulamaları (Edited by Assoc. Prof. Ö. Yeşil-Çeliktaş) p.199–204
  • Zeinali, S., Çetin, B., Oliaei, S., Karpat, Y. (2015). "Fabrication of continuous flow microfluidics device with 3D electrode structures for high throughput DEP applications using mechanical machining", Electrophoresis, Special Issue on Dielectrophoresis, v.36(13) p.1432-1442, Full Text, DOI: http://dx.doi.org/10.1002/elps.201400486
  • Barışık, M., Yazıcıoğlu, A.G., Çetin, B., Kakaç, S. (2015). "Analytical solution of thermally developing microtube heat transfer including axial conduction", Int. Comm. Heat and Mass Transfer, v.67 p.81-88, Full Text
  • Karakaya, Z., Baranoğlu, B., Çetin, B., Yazıcı, A. (2015). "A parallel boundary element formulation for tracking multiple particle trajectories in Stoke's flow for microfluidic applications", CMES-Computer Modeling in Engineering and Science, v.104(3) p.227-249, Full Text
  • Çetin, B., Koska, K., Erdal, M. (2015). "Warpage Characterization of Microchannels Fabricated by Injection Molding", ASME J. Micro and Nano-Manufacturing, v.3(2) p.021005, Full Text
  • Çetin, B., Li, D. (2015). "Temperature Gradient Generation and Control", Encyclopedia of Micro and Nanofluidics (2nd Edition), Springer p.3225-3227
  • Çetin, B., Baranoğlu, B. (2015). "Boundary-Element Method in Microfluidics", Encyclopedia of Micro and Nanofluidics (2nd Edition), Springer p.202-213
  • Çetin, B., Salemmilani, R., Li, D. (2015). "Microfluidic Rotary Pump", Encyclopedia of Micro and Nanofluidics (2nd Edition), Springer p.2000-2004
  • Çetin, B., Salemmilani, R., D. Li (2015). "Ultrasonic pumps", Encyclopedia of Micro and Nanofluidics (2nd Edition), Springer p.3394-3397
  • Çetin, B., Zeinali, S., Li, D. (2015). "Microfluidic Optical Devices", Encyclopedia of Micro and Nanofluidics (2nd Edition), Springer p.1980-1984
  • Çetin, B., Zeinali, S., Li, D. (2015). "Magnetic Pumps", Encyclopedia of Micro and Nanofluidics (2nd Edition) p.1690-1695
  • Çetin, B., Taze, S., Li, D. (2015). "Methods for Pressure Measurements", Encyclopedia of Micro and Nanofluidics (2nd Edition), Springer p.2828-2834
  • Büyükkoçak, S., Özer, M.B., Çetin, B. (2015). "Microscale Acoustofluidics", Encyclopedia of Micro and Nanofluidics (2nd Edition), Springer p.2149-2158
  • Büyükkoçak, S., Özer, B., Çetin, B. (2014). "Numerical modeling of acoustophoretic particle separation for microfuildics", Microfluid Nanofluid, v.17(6) p.1025-1037, Full Text
  • Çetin, B., Zeinali, S. (2014). "Analysis of heat transfer for a low Peclet number microtube flow using second-order slip model: An extended-Graetz problem", J. Engineering Mathematics, v.89(1) p.13-25, Full Text
  • Çetin, B., Özer, M.B., Solmaz, M.E. (2014). "Microfluidic bio-particle manipulation for biotechnology", Biochemical Engineering Journal, v.92 p.63-82, Full Text
  • Cole, K., Çetin, B., Brettmann, L. (2014). "Microchannel heat transfer with slip flow and wall effects", AIAA J. Thermophysics and Heat Transfer, v.28(3) p.455-462, Full Text
  • Çetin, B., Aşık, M.D., Taze, S. (2014). "Design and fabrication of a microfluidic device for synthesis of chitosan nanoparticles", ASME J. Nanotechnology in Engineering and Medicine, v.4(3) p.031004, Full Text
  • Çetin, B. (2013). "Effect of thermal creep on heat transfer for a 2D microchannel flow: An analytical approach", ASME J. Heat Transfer, Special Issue on Microchannel Heat Transfer, v.135(10) p.101007, Full Text
  • Çetin, B., Li, D. (2011). "Dielectrophoresis in microfluidics technology", Electrophoresis, Special Issue on Dielectrophoresis, v.32 p.2410–2427
  • Çetin, B., Bayer, O. (2011). "Evaluation of Nusselt number for a flow in a microtube using second-order slip model", Thermal Science, v.15(Suppl. 1) p.103-109, Full Text
  • Çetin, B., Cole, K. (2011). "The effect of axial conduction on heat transfer in a liquid microchannel flow", Int. J. Heat and Mass Transfer, v.54 p.2542-2549, DOI: http://dx.doi.org/10.1016/j.ijheatmasstransfer.2011.02.007
  • Çetin, B., Li, D. (2010). "Lab-on-a-chip device for continuous particle and cell separation based on electrical properties via AC-dielectrophoresis", Electrophoresis, v.31 p.3035-3043, DOI: http://dx.doi.org/10.1002/elps.20090007830
  • Çetin, B., Yazıcıoğlu, A.G., Kakaç, S. (2009). "Slip-flow heat transfer in microtubes with axial conduction and viscous dissipation-an extended Graetz problem", Int. J. Thermal Sciences, v.48 p.1673-1678, DOI: http://dx.doi.org/10.1016/j.ijthermalsci.2009.02.002
  • Çetin, B., Kang, Y., Wu, Z., Li, D. (2009). "Continuous particle separation with localized AC-DEP using embedded electrodes and an insulating hurdle", Electrochimica Acta, v.54 p.1715-1720, DOI: http://dx.doi.org/10.1016/j.electacta.2008.09.062
  • Çetin, B., Kang, Y., Wu, Z., Li, D. (2009). "Continuous particle separation by size via AC-DEP using a lab-on-a-chip device with 3D electrodes", Electrophoresis, v.30 p.766-772, DOI: http://dx.doi.org/10.1002/elps.200800464
  • Çetin, B., Li, D. (2009). "Continuous particle separation based on electrical properties using AC-DEP", Electrophoresis, v.30 p.3124-3133, DOI: http://dx.doi.org/10.1002/elps.20090007830
  • Çetin, B., Yazıcıoğlu, A.G., Kakaç, S. (2008). "Fluid Flow in microtubes with axial conduction including rarefaction and viscous dissipation", Int. Comm. Heat and Mass Transfer, v.35 p.535-544, DOI: http://dx.doi.org/10.1016/j.icheatmasstransfer.2008.01.003
  • Çetin, B., Li, D. (2008). "Effect of Joule heating on electrokinetic transport", Electrophoresis, v.29(5) p.994-1005, DOI: http://dx.doi.org/10.1002/elps.200700601
  • Çetin, B., Travis, B.E., Li, D. (2008). "Analysis of the electro-viscous effects on pressure-driven liquid flow in a two-section heterogeneous microchannel", Electrochimica Acta, v.54 p.660-664, DOI: http://dx.doi.org/10.1016/j.electacta.2008.07.008
  • Çetin, B., Yuncu, H., Kakaç, S. (2006). "Gaseous flow in microconduits with viscous dissipation", Int. J. Transport Phenomena, v.8(4) p.297-315, Full Text
  • Çetin, B., Li, D. (2008). "Microfluidic Rotary Pump", Encyclopedia of Micro and Nanofluidics (1st Edition), Springer p.1188-1189, Full Text
  • Çetin, B., Li, D. (2008). "Temperature Gradient Generation and Control", Encyclopedia of Micro and Nanofluidics (1st Edition), Springer p.1993-1994, Full Text
  • Çetin, B., Li, D. (2008). "Methods for Pressure Measurements", Encyclopedia of Micro and Nanofluidics (1st Edition), Springer p.1743-1745, Full Text
  • Çetin, B., Li, D. (2008). "Magnetic Pumps", Encyclopedia of Micro and Nanofluidics (1st Edition), Springer p.1040-1043, Full Text
  • Çetin, B., Li, D. (2008). "Microfluidic Optical Devices", Encyclopedia of Micro and Nanofluidics (1st Edition), Springer p.1186-1187, Full Text
  • Çetin, B., Li, D. (2008). "Ultrasonic pumps", Encyclopedia of Micro and Nanofluidics (1st Edition), Springer p.2128-2129, Full Text